Volume : X, Issue : V, May - 2020

EFFECTS OF SERUM VITAMIN D DEFICIENCY ON KNEE OSTEOARTHRITIS

Dr. Subhra Sucharita Sahoo, Dr. Jayeeta Bhadra, Dr. Bhaskar Chandra Kabi

Abstract :

Background: Normal bone and cartilage metabolism depends on the presence of vitamin D. Suboptimal levels of vitamin D have been shown to have adverse effects on calcium metabolism, osteoblastic activity, matrix ossification, bone density, and articular cartilage turnover there by influence the knee joint cartilage and lead to development and progression of knee Osteoarthritis (OA). So this study was an attempt to explore the status of serum vitamin D (25–OHD) levels in patients with knee OA compared with controls. Methods: A total of 100 patients with knee OA and 100 controls were taken in the study. Serum 25–OHD was measured by the ELISA method and concentrations <20 ng/ml were considered as deficient levels. Mann–Whitney U test was used for comparisons of means and the association of vitamin D deficiency and knee OA was assessed using chi– square test with calculation of odds ratio (OR) and its 95% confidence interval (95% CI). Results: The mean ages of cases and controls were 59.58±11.37 and 58.46±10.58 years, respectively (P=0.234). In the entire population the mean serum 25–OHD in OA patients was significantly lower than controls (P = 0.004*), but in subgroup analysis the OA patients aged >=60 years the mean serum 25–OHD was not significantly lower than controls (46.08±24.73 ng/ml vs 46.74 ± 24.31 ng/ml, P = 0.93) whereas in OA patients aged <60 years the mean serum 25–OHD was significantly lower than that of controls (P=0.00012*). Conclusion: These findings indicate a significant association between serum 25–OHD deficiency and knee OA in patients aged < 60 years and suggest serum 25–OHD measurement should be done in any patient with symptoms suggestive of knee OA particularly at the initial stage of disease.

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

EFFECTS OF SERUM VITAMIN D DEFICIENCY ON KNEE OSTEOARTHRITIS, Dr. SUBHRA SUCHARITA SAHOO, Dr. JAYEETA BHADRA, Dr. BHASKAR CHANDRA KABI INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-5 | May-2020

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