Volume : V, Issue : VII, July - 2015

EFFECTS OF STATIN THERAPY ON PLASMA GLUCOSE AND GLYCATED HEMOGLOBIN

Shashi R. M. Yadav, A. D. Deepak, Vijay K. Shah

Abstract :

<p> Introduction:As statin acts by inhibiting rate limiting step in cholesterol biosynthesis, is most commonly employed drugs in hypercholesterolaemic patients. Beside its several beneficial effects in coronary heart patients, it is supposed to confer an increased risk of developing diabetes. Thus there is need of proper investigations and demonstrations of such adverse effects of statin therapy. Therefore, this study was undertaken to monitor the adverse effects of statin therapy on hypercholesterolemic patients. Objective: The present study evaluated the effects of statin therapy on plasma glucose and glycated haemoglobin in non–diabetic patients. Method:A total of 40 patients were recruited in the study after obtaining informed written consent.They weredivided into two groups. Group 1 included subjects to be prescribed with statin and Group 2 included subjects with 3 months prescription of statin drug.Biochemical parameter like plasma glucose was estimated by colorimetric method on autoanalyser and HbA1c by Immunoturbidimetric method by D10 analyser. Result: There were statistically significant differences found in glycemic and lipid profiles in group 1 and group 2 (0.001). There were significantly decreased levels of total cholesterol, triacylgltcerol, LDL and VLDL (0.001) while significantly increased levels of HbA1c (0.001) in group 2 than in group1. Similarly there were significantly increased levels of plasma glucose and HbA1c (0.001) in group 2 than in group 1. Conclusion: We suggest from our study that patients on statin therapy should have a frequent monitoring of plasma glucose levels and HbA1c levels to avoid complications like Hyperglycaemia, Myopathy, Hepatotoxicity, Cataract and many more.</p>

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Shashi R.M. Yadav, A.D. Deepak Effects of Statin Therapy on Plasma Glucose and Glycated Hemoglobin Indian Journal of Applied Research, Vol.5, Issue : 7 July 2015

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