Volume : VIII, Issue : II, February - 2018

Efficacy And Safety Of Tablet Famciclovir 500 Mg (Penvir) In The Treatment Of Ocular Herpes

Shobha Jc, Tabitha Ohol

Abstract :

 

Objective: To assess the efficacy and safety of oral tablet famciclovir 500mg in the management of Ocular Herpes.

Patients and Methods: Patients diagnosed with ocular herpes were enrolled as per inclusion and  exclusion criteria. Ophthalmic clinical manifestations, severe and non severe ocular manifestations were recorded at baseline and at day 3 and day 7. Study medication   tab famciclovir 500mg was issued to the patients and advised to take orally, one tablet three times a day for 7 days. Safety evaluation was done on day 3 and day 7.

Results: Ophthalmic clinical manifestations, forehead rash, eyelid oedema, photophobia and conjunctival episcleral and circumcorneal conjunctival hyperaemia were statistically significantly reduced on day 3 and day 7. (p<0.05, p<0.01, p<0.001). Statistically significant reduction in ocular pain was seen on day 7 (p<0.01).   Severe ocular manifestations, deep keratitis resolved completely on day 7, keratic precipitates and synechia resolved on day 3.  Non–severe ocular manifestations, episcleritis resolved on day 7. Adverse drug reactions reported were nausea, headache, gastrointestinal intolerance, itching and abdominal cramps, which were of mild to moderate intensity, resolved completely in all the patients. Clinical outcome, analyzed as the cure and improvement taken as success, the treatment was successful in all the patients treated.

Conclusion: In this present study, tablet famciclovir 500mg three times a day for 7 days, was found to be effective in decreasing the symptoms of Ocular herpes and preventing the ocular complications. The study medication was well tolerated.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Shobha JC, Tabitha Ohol, Efficacy And Safety Of Tablet Famciclovir 500 Mg (Penvir) In The Treatment Of Ocular Herpes, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-2 | February-2018


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