Efficacy of a novel risk score in prediction of systemic hypertension in young male patients; the role of laboratory biomarkers in primary prevention.

Amr Shaaban Hanafy

Volume : VI, Issue : IV, April - 2016

Efficacy of a novel risk score in prediction of systemic hypertension in young male patients; the role of laboratory biomarkers in primary prevention.

Amr Shaaban Hanafy

Abstract :

Backgrounds: There is a growing increase in the appearance of hypertension in young adults. The aim of this study is to analyze the metabolic variables in this group of patients and establishment of a predicting clinical score. Methods: 240 young aged male patients presented with accidentally discovered systemic hypertension were selected. Specific risk factors which could be associated with hypertension as BMI, WC, AST, ALT, GGT, FBS, insulin, HOMA–IR, QUICKE, trigycerides, uric acid, ferritin, MPV, plasma viscosity and fatty liver were selected. A control group was taken (n=50). Validation group (100) was used to assess the predictive power of the score. Results: Diastolic hypertension associated with ALT (P=0.002), QUICKI (P=0.035), Uric acid (P=0.001), MPV (P=0.003), PV (P=0.000), Fatty liver (P=0.019). Systolic hypertension with BMI (P=0.038), GGT (P=0.037), FBS (P=0.008), QUICKI (P=0.01), MPV (P=0.02), Fatty liver (P=0.003). A score composed of BMI>26 K/m2, ALT > 34 IU/L, GGT > 32 IU/L, FBS > 100 mg/dl, QUICKI< 0.33, MPV > 10.5 fl, uric acid > 6mg/dl, PV > 1.8mps/s, severity of fatty liver by USG. Conclusion: The score was successful in identifying metabolically prone patients at risk of systemic hypertension.