Efficacy of Intrathecal Dexmedetomidine and Fentanyl as Adjuvants To 0.5% Hyperbaric Bupiva�caine in Spinal Anaesthesia

Dr. Padma Vishal; Dr. S K Veereswara Raju

Volume : VII, Issue : I, January - 2017

Efficacy of Intrathecal Dexmedetomidine and Fentanyl as Adjuvants To 0.5% Hyperbaric Bupiva�caine in Spinal Anaesthesia

Dr. Padma Vishal, Dr. S K Veereswara Raju

Abstract :

To compare the effects of intrathecal dexmedetomidine and fentanyl as adjuvants to hyperbaric bupivacaine with a control group with regards to time of onset of sensory and motor blockade, Duration of sensory blockade and motor blockade, Two segment sensory regression time, Duration of effective post– operative analgesia and incidence of side effects. A randomized, prospective study, after obtaining ethical committee approval in Asram hospital and written informed consent of patients was conducted on 100 Adult Patients of either sex, aged between 20 to 45 years, of physical status ASA Grade I and Grade II undergoing elective lower limb surgeries under spinal anaesthesia. Patients were divided into 2 groups of 30 each. Group D received 15mg hyperbaric bupivacaine with 10mcg dexmedetomidine. Group F received 15mg hyperbaric bupivacaine with 25mcg fentanyl. The time of onset of sensory and motor blockade and the duration of two segment sensory regression time, sensory, motor blockade and duration of effective post op analgesia was statistically significant in group D compared to F. Intrathecal Dexmedetomidine is associated with faster onset of sensory and motor blockade, with significantly prolonged sensory and motor blockade and less requirement of rescue analgesia compared to fentanyl.