IJAR - Indian Journal of Applied Research

Alok N; Vikram M. Shivappagoudar; Latha P. John

Volume : VIII, Issue : XII, December - 2018

Efficacy of Ketamine-Midazolam Combination in Prevention of Shivering during Spinal Anaesthesia- A Comparative Study

Alok N, Vikram M. Shivappagoudar, Latha P. John

Abstract :

Shivering is a frequently noted side effect of spinal anaesthesia. We conducted a prospective randomized study involving 210 patients posted for elective lower limb surgery under subarachnoid block. Patients in group A received ketamine 0.25 mg/kg with midazolam 0.02mg/kg, group B patients received ketamine 0.25 mg/kg with midazolam 0.04 mg/kg and patients in group C received normal saline. The incidence of shivering in group C was 67% which was statistically significant while it was 2.85% in group A and 0.7% in group B. By the end of two hours the shivering incidence was 17%, 21.4% and 11.4% in group A, group B and group C respectively. Maximum mean sedation score was noted in group B which was statistically significant. Ketamine–midazolam combination administered prophylactically results in significant reduction of shivering but the effect is short lived. Higher dose of midazolam offers no advantage and results in excessive sedation.