IJAR - Indian Journal of Applied Research

Dr.S.Loganathan

Volume : VII, Issue : XI, November - 2017

Efficacy of Ondansetron in the control of nausea and vomiting during and after caesarean section under spinal anaesthesia- A Randomized Double blinded Controlled Trial

Dr. S. Loganathan

Abstract :

Background; Ondansetron has been successfully used to control emesis in various clinical situations mainly during chemotherapy, radiotherapy and operative and postoperative conditions. Aim of this study is to evaluate the efficacy and safety of ondansetron in the control of nausea, retching and vomiting during and after caesarean section under spinal anaesthesia.

Materials and Methods; This randomized controlled trial conducted among 50 pregnant patients were scheduled to undergo elective caesarean section belonging to ASA physical status 1 and 2 in the age of 20–40 years. Group I (study group) received ondansetron 4 mg intravenously and Group II patient (control group) received placebo injection or normal saline intravenously after delivery of the baby and umbilical cord clamping.

Results; The age,height,weight,gravidity and initial mean BP were similar in both groups. There is statistically significant difference among the placebo group and ondansetron group in control of nausea and vomiting during and after caesarean section under spinal anaesthesia as detected by chi square test by which the probability was <0.01.

Conclusion; In this study, it is inferred that intraoperative intravenous injection of ondansetron 4 mg is highly efficacious in reducing the incidence of vomiting and the severity of nausea during and after caesarean section under spinal anaesthesia and also very safe with minimal side effects