Efficacy of Ramosetron and Ondansetron in prevention of post-operative PONV in cases under abdominal surgeries - A comparative study.

Dr. Badri Narayana Chigullapally

Volume : VIII, Issue : XII, December - 2018

Efficacy of Ramosetron and Ondansetron in prevention of post-operative PONV in cases under abdominal surgeries - A comparative study.

Dr. Badri Narayana Chigullapally

Abstract :

Post–operative nausea and vomiting (PONV) is an important cause of patients discomfort after surgery. Selective 5–hydroxytryptamine type 3 (5–HT3) receptor antagonists are considered first–line for prophylaxis, ondansetron being the most commonly used agent. Ramosetron, another selective 5–HT3 receptor antagonist, is more potent and longer acting than ondansetron. This study designed to assess the efficacy & safety of Ramosetron and Ondansetron in preventing the PONV after elective abdominal surgeries undergone spinal anaesthesia. A total 180 patients aged between 21–60 years with ASA class I and II, allotted for abdominal surgeries under spinal anaesthesia were recruited. Based on drug administered cases were equally divided in to 3 groups, group 1 with Ondansetron (4mg), group 2 with Ramosetron (0.3mg) and group 3 with Normal saline (only rescue anti– emetic). The incidence of nausea, vomiting and retching was studied for a period of 24 hours post operatively followed by PONV scoring system. In group 1, complete response (Score–0) was 88.3%, 95%, 96.6% and 96.6% in first 6 hours, 6–12hrs, 12–18hrs and 18–24hrs respectively. Complete response was 90% in first 6 hrs, 98.3% in 6–12hrs, 98.3% in 12–18hrs and 100% in 18–24hrs. In group 3, complete response was 76.6% in first 6 hrs, 80% in 6–12hrs, 90% in 12–18hrs and 91.6% in 18–24hrs. Ramosetron 0.3mg with has a significantly higher complete response than the Ondansetron 4mg (96.6% vs 94.1%) in the 24 hour postoperative period.