Volume : X, Issue : I, January - 2020

ELLUCIDATING THE ROLE OF INFLAMMATION IN CARDIOVASCULAR DISORDERS

Dr Susanta Pradhan, Dr Snehalata Mallick

Abstract :

Atherosclerosis is a progressive pathology leading to cardiovascular disorders (CVDs) viz., stroke, coronary artery disease, and peripheral arterial diseases. Current understanding of atherosclerosis has established the role of vascular inflammation along with the lipid accumulation. Molecular mechanism of vascular inflammation elucidates the role of both innate as well as adaptive immunity in the initiation and progression of atherosclerosis. Atherosclerosis is initiated by the endothelial injury or deposition of low–density lipoproteins (LDLs) within the arterial wall. These LDLs are highly prone to oxidation or modification and trigger innate and adaptive immunity. As a result of the activation of the immune response, monocytes/macrophages, neutrophils, T lymphocytes, and B lymphocytes are triggered. Monocytes/macrophages take up oxidized LDLs and initiate the formation of foam cells that eventually results in plaque formation. T–cells along with neutrophils have been reported to further promote the formation of foam cells. These inflammatory responses are triggered due to the release of various cytokines viz., high–sensitivity C–reactive protein and interleukin–6, which now serve as biomarkers and prediction tools for the CVDs. Understanding of the role of inflammation in CVDs has opened up a new therapeutic approach for the prevention and the treatment of CVDs. Current research and trials are now focused on reducing chronic vascular inflammation for the treatment of CVDs. The present review will focus on the molecular mechanism of the inflammation leading to atherosclerosis, cytokines that are being used as a diagnostic tool and the novel treatment approaches for reducing vascular inflammation that are being evaluated in trials for the treatment of CVDs.

Keywords :

Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

ELLUCIDATING THE ROLE OF INFLAMMATION IN CARDIOVASCULAR DISORDERS, Dr Susanta Pradhan, Dr Snehalata Mallick INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-1 | January-2020

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