Epidemiology, clinical and histopathological profile of patients with primary localized cutaneous amyloidosis (PLCA) in a tertiary care hospital in Mumbai

Dr Swagata Arvind Tambe; Dr Hemangi Jerajani

Volume : IX, Issue : X, October - 2019

Epidemiology, clinical and histopathological profile of patients with primary localized cutaneous amyloidosis (PLCA) in a tertiary care hospital in Mumbai

Dr Swagata Arvind Tambe, Dr Hemangi Jerajani

Abstract :

Background: Primary localized cutaneous amyloidosis (PLCA) is one of the common pigmentary disorders in dermatology. Aims: To study epidemiological and clinical profile of patients with PLCA. To study utility of H & E stain, Thioflavin–T stain & direct immunofluorescence (DIF) for demonstration of amyloid deposits. Methods: Patients of both sexes, aged 18 to 65 years were included. Detailed history & clinical examination was followed by skin biopsy for H& E stain, Thioflavin–T stain and DIF studies. Results: Sixty–five patients with clinical diagnosis of PLCA were studied. Mean age of presentation was 38.76 years with female preponderance. Macular amyloidosis (84.61%) was the commonest type followed by lichen amyloidosis (50%). Amyloid was demonstrated by H&E stain in 63.07 % of the cases, by Thioflavin–T stain in 64.61 % of the cases and by DIF in 44.61 % of the cases. Conclusions: H& E stain was found to be equally effective for diagnosis of PLCA compared to special stains.