Erythroleukemia with Complex Cytogenetic  Abnormalities: A case report with review of literature

Pooja K Suresh; Purnima S Rao; Urmila N Khadilkar

Volume : III, Issue : VII, July - 2013

Erythroleukemia with Complex Cytogenetic Abnormalities: A case report with review of literature

Pooja K Suresh, Purnima S Rao, Urmila N Khadilkar

Abstract :

Acute Erythroleukemia (AEL) is a rare type of hematopoietic neoplasm, having a prevalence of 3–5% of all Acute Myeloid Leukemia (AML). We present a case report of acute erythroleukemia, a rare type of AML, with complex cytogenetic abnormalities. A 54–year old male presented with low grade fever and significant weight loss. Complete hemogram and a peripheral smear revealed pancytopenia with 18% blasts. It also showed features of hemolysis. Bone marrow (BM) study showed erythroid hyperplasia with erythroblasts constituting 85% of all nucleated cells and 21% myeloid blasts among non–erythroid cells. Flow cytometry revealed 23% blasts positive for CD33, CD34, CD117, CD36 and HLA–DR. Cytogenetic study revealed hypotetraploidy with numerous structural abnormalities indicating poor prognosis.