IJAR - Indian Journal of Applied Research

S. Syed Ibrahim; Mangalabharathi Sundaram; Krishna Dathan; R. Shanmugasundaram

Volume : VII, Issue : VII, July - 2017

Etiology and Short–Term Outcomes of Neonatal Seizures in A Tertiary Care Hospital in South India

S. Syed Ibrahim, Mangalabharathi Sundaram, Krishna Dathan, R. Shanmugasundaram

Abstract :

Background: Neonatal seizures are the most common manifestation of neurological disorders in the newborn period and early detection of predictors of adverse outcome will be helpful for neonatologists to plan management, follow up and rehabilitation in advance so that neurological disability can be minimized.

Objectives: To determine the etiology, incidence of various clinical seizure types, and prognostic factors associated with poor short–term outcome among neonates admitted with neonatal seizures.

Methods: This is a nested case control study in a descriptive cohort, conducted in Department of neonatology, Dr Mehta’s Hospital Chennai between May 2011 to November 2012.All the neonates who presented with clinically identifiable seizures were enrolled in the study. Seizure etiology was based on positive clinical data, laboratory findings, EEG and /or imaging studies of the ain (ultrasonography, CT Scan, or MRI).

Results: Hypoxic ischemic encephalopathy, radiological findings and EEG findings were significantly associated with outcome.

Conclusion: Hypoxic Ischemic Encephalopathy was the most common cause of neonatal seizure and most common seizure type was multifocal clonic type. The most common diagnosis associated with neonatal seizure that carry worse mortality were hypoxic ischemic encephalopathy and inborn errors of metabolism.