Evaluate Analgesic and Anti-inflammatory Effect of Ethanolic Leaves Extract of Solanum virginianum (L)

Geeta Devi Sahu; Vishal Shrivarstava; Parul Senger; Jay Prakash Rai

Volume : X, Issue : VI, June - 2020

Evaluate Analgesic and Anti-inflammatory Effect of Ethanolic Leaves Extract of Solanum virginianum (L)

Geeta Devi Sahu, Vishal Shrivarstava, Parul Senger, Jay Prakash Rai

Abstract :

Present study was evaluated the Analgesic and Anti–inflammatory properties of ethanolic leaves extracts of Solanum virginianum (L). (ELSvE). In this study, (ELSvE) in doses of 200 and 400 mg/kg was used. The phytochemical analysis, analgesic activity and anti–inflammatory activity was evaluated using hot plate method, tail immersion test, acetic acid induced writhing response in mice and carrageenan–induced paw edema in rats, cotton pellet induced granuloma method in mice. Intensive investigation on phytochemical constituents It was found that various phytochemical were present Proteins & Amino acids, Saponins and high amount of flavonoids. It was found that the all (ELSvE) extracts showed significant (p<0.05 and p< 0.01) analgesic activity but among the two doses, 400 mg/kg showed highest analgesic activity at reaction time 120 min. There was a significant reduction of pain full sensation due to tail immersion in warm water. The maximum inhibitory effect of (ELSvE) Showed significant (p< 0.01) at 90 min post dose in 400 mg/kg and also showed a dose dependent analgesic activity. Injection of acetic acid into control mice produced 52.4=2±0.5 writhes. Pretreatment with (ELSvE) at doses of 200 and 400 mg/kg reduced the number of writhes 38.2±1.5 (25.30 % protection) and 32.2±2.5 (38.18 % protection) respectively. Among the two doses 200, 400 mg/kg showed the slightly lower analgesic activity than standard drug Diclofenac Sodium 28.8±1.2 (54.25 % protection). It was observed that the onset of writhing was delayed and duration of writhing was shortened. In Carrageenan–Inuced Paw Edema in Rats, the dose of 400 mg/kg exhibited a significant inhibition of 48 % after 3 h, the effect increased after 3h (52%). In Anti–inflammatory activity the extracts showed significant and similar to that of indomethacine (10 mg/kg). Cotton Pellet–Induced Granuloma Method in Rats Among the two dose 400 mg/kg showed the slightly lower reduced weight of granumola than standard drug dexamethazone 28.92±0.04 (29.8% inhibition). ELSvE possesses several important pharmaceutical and pharmacological properties. The current study describes that (ELSvE) has significant analgesic anti–inflammatory properties. Conclusion of the study is that this herbal medicine can be used as an alternative therapy for the treatment of minor to moderate types of as a painkiller and inflammation