Evaluate antifertility effects of Tecomella undulata  to develop an oral male contraceptive.

Pawan Kumar Soni; Pratap Chand Mali

Volume : VII, Issue : VII, July - 2017

Evaluate antifertility effects of Tecomella undulata to develop an oral male contraceptive.

Pawan Kumar Soni, Pratap Chand Mali

Abstract :

Objectives– To evaluate antifertility activity of Tecomella undulata bark to develop a reversible male contraceptive.

Methods– 50% petroleum ether extract of Tecomella undulata bark was administered orally at three different doses in male Wistar rats for 60 days. The clinical investigation of serum was performed, reproductive organs weight was recorded. Sperm density and motility were calculated. The tissues were analyzed for sialic acid, protein, fructose and cholesterol contents. The level of testosterone, FSH and LH were measured. The damage of sperms DNA was assessed by comet assay. Data were analyzed statistically using Student‘t’–test.

Key findings– Data do not showed any alteration in general body weights; but weights of reproductive organs, sperm density and motility were declined signiﬁcantly, followed to decrease fertility. Levels of testosterone, FSH and LH were signiﬁcantly decreased. The levels of sialic acid, protein, glycogen and cholesterol contents were reduced significantly in reproductive organs. Testis histoarchitecture exhibits degenerative changes in germinal epithelium and reduced numbers in spermatocytes, spermatids. Comet assay expressed DNA damage in sperms of extract treated groups.

Conclusions– It can be concluded that oral administration of T.undulata bark extract caused androgen deprivation affects spermatogenesis in treated rats might be due to antiandrogenic nature of treatment.