Volume : III, Issue : VII, July - 2014

Evaluating the Interleukin 17 serum level in psoriatic patients from Eastern Egyptian population

Yousry Abo Elmajd, Hend Ibrahim, Nermin Raafat, Yousry Abdel Mawla

Abstract :

Objectives: Cytokines released by T helper 17 (Th17) cells maintain psoriatic inflammation. The aim of the study was to determine the serum level of IL–17 in psoriatic patient and to evaluate the effect of the local treatment on IL–17 level.

Materials and Methods: Ninety subjects from both sexes with ages ranging from 20–40 years old were instructed to apply 0.64 mg of Betamethasone Dipropionate (equivalent to 0.5 mg (0.05%) of Betamethasone) and 30 mg (3%) of salicylic acid ointment twice per day for three weeks. For scalp psoriasis, patients were advised to use 0.64 mg of Betamethasone Dipropionate, equivalent to 0.5 mg (0.05%) of Betamethasone and 20mg (2%) of Salicylic acid lotion twice per day for three weeks. Serum IL–17 concentrations were determined by ELISA on day 0 and day 21.Psoriasis area severity score index(PASI) was evaluated.

Results: A statistically significant higher level of IL–17 (p< 0.05) was observed in psoriatic patients versus control before therapy. On the other hand, a statistically significant lower level of IL–17 (p< 0.05) was observed in psoriatic patients after immunosuppressive therapy (at day 21) as compared to IL–17 levels before therapy. No significant difference (p> 0.05) in psoriasis area severity score index (PASI) in patients after treatment was observed. Further analysis indicated that there was no significant correlation between serum IL–17 level and PASI Score before therapy. Conclusion: IL–17 is implicated in psoriasis immunopathogenesis and its level is reduced by local application of immunosuppressive drug for 3 weeks

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Yousry Abo Elmajd, Hend Ibrahim, Nermin Raafat, Yousry Abdel Mawla Evaluating the Interleukin 17 serum level in psoriatic patients from Eastern Egyptian population Indian Journal of Applied Research, Vol.4, Issue.7 July 2014

Number of Downloads : 685

References :