Evaluation of Angiotensin II and ACE Activity in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Dr Preeti Chauhan; Dr Parijat Gogoi; Dr Rajesh Chetiwal

Volume : IX, Issue : VIII, August - 2019

Evaluation of Angiotensin II and ACE Activity in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

Dr Preeti Chauhan, Dr Parijat Gogoi, Dr Rajesh Chetiwal

Abstract :

COPD represents an important public health challenge and is a major cause of chronic morbidity and mortality throughout the world. Salt and water retention eventually resulting in edema formation is a frequently occurring feature in advanced COPD patients and it indicate a poor prognosis. This study was done to explore the potential role of Renin Angiotensin Aldosterone System (RAAS) in the pathogenesis of salt and water retention and pulmonary hypertension in patients of acute exacerbation of COPD. Our study reveals that in such patients there is significant alteration of RAAS system which correlated with changes in ABG. These alterations may play an important role in the pathogenesis of salt and water retention and pulmonary hypertension.