Volume : VII, Issue : V, May - 2017

Evaluation of anti–diarrheal activity in seed extracts of Pongamia pinnata (Fabaceae)

Dahikar S. B. , Bhutada S. A.

Abstract :

 The purpose of the present study was to investigate scientifically the anti–diarrheal activity of seed extracts of Pongamia Pinnata by castor oil–induced diarrhoea model in Wister albino rats. Anti–diarrheal effect was evaluated by castor oil induced diarrhea. Loperamide 1mg/kg was used as standard drugs. Pet ether, ethanol, aqueous extract at doses 30 mg/kg, 250mg/kg, 100mg/kg respectively was investigated for anti–diarrheal activity in term of reduction in the rate of defecation of faces in castor–oil induced diarrhea. In castor oil induced diarrhea, petroleum ether, ethanol and aqueous extract of Pongamia pinnata seeds significantly reduce the mean weight of faces when compared to standard drug. Experimental findings showed that ethanol extract of seeds of Pongamia pinnata possess significant anti–diarrheal activity as that of pet ether and aqueous extracts. Therefore it may be a potent source of anti–diarrheal drug in future.  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dahikar S.B., Bhutada S.A., Evaluation of anti–diarrheal activity in seed extracts of Pongamia pinnata (Fabaceae), INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾5 | May‾2017

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