EVALUATION OF ANTIMITOTIC ACTIVITY OF Aplotaxis auriculata RHIZOMES USING Allium Cepa ROOT MERISTAMATIC CELLS

R Shalini; S Velavan

Volume : VII, Issue : XII, December - 2017

EVALUATION OF ANTIMITOTIC ACTIVITY OF Aplotaxis auriculata RHIZOMES USING Allium Cepa ROOT MERISTAMATIC CELLS

R Shalini, S Velavan

Abstract :

The aim of this work was investigate the antimitotic activity of Aplotaxis auriculata rhizomes. The inhibitory effect of methanolic extract of Aplotaxis auriculata rhizome was evaluated on the growth and mitotic activity of A. cepa root meristems and the effect was compared with standard anticancer drug Methotrexate. A progressive increase in root length (32.40mm), root numbers (18) and mitotic index (85.17%) observed in control group after 96 hrs of experimental period. The methanolic extract of Aplotaxis auriculata rhizome and Methotrexate produced root decay and decreased the root length and root number significantly at 96 h as compared to control (p<0.05). Maximum numbers of non–dividing cells were observed. Aplotaxis auriculata rhizome has significant activity in root length, number and mitotic index and near to the standard