Evaluation of antinociceptive potential of new heterocyclic derivatives of 3�formyl�4�hydroxycoumarin in rats

Razi Ahmad; Sana Rehman; Mohammad Asad; Zeeba N. Siddiqui

Volume : VI, Issue : XII, December - 2016

Evaluation of antinociceptive potential of new heterocyclic derivatives of 3�formyl�4�hydroxycoumarin in rats

Razi Ahmad, Sana Rehman, Mohammad Asad, Zeeba N. Siddiqui

Abstract :

Coumarin is a fragrant organic chemical compound in the benzopyrone chemical class. It is a natural substance found in many plants. Coumarin has been used as an aroma enhancer in pipe tobaccos and certain alcoholic drinks. It have multiple biological activities; various coumarin–related derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase pathways of arachidonate metabolism. Several natural or synthetic coumarins with various hydroxyl and other substitutes were found to inhibit lipid peroxidation and to scavenge hydroxyl radical and superoxide anion and to influence processes involving free radical mediated injury. Thus, the objective of the present study was to evaluate the analgesic activities of various heterocyclic derivatives of 3–formyl–4–hydoxycoumarin (synthesized by us) in animal models. All compounds synthesized were evaluated for the above activity and their effects were compared with the standard drugs. The nociceptive response were performed in adult male Wistar rats using hot plate and formalin tests. The test compound produced significant antinociceptive activity in the hotplate (central) as well as in formalin tests (central and peripheral) suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response.