Evaluation of Antioxidant and Antitumor Activities of  Some Prepared Nitrogen Heterocycles

Mohamed Abd El-Moneim; Ibrahim M. El-Deen; Wessam Abd El-Fattah

Volume : III, Issue : VII, July - 2013

Evaluation of Antioxidant and Antitumor Activities of Some Prepared Nitrogen Heterocycles

Mohamed Abd El Moneim, Ibrahim M. El Deen, Wessam Abd El Fattah

Abstract :

4–Benzylidene–2–(p–chlorophenyl)–4H–oxazol–5–one (2) was prepared via cylcocondensation of N–(p–chlorobenzoyl) glycine with benzaldehyde in presence of fused sodium acetate and acetic anhydride. Condensation of 2 with semicarbazide hydrochloride in presence of fused sodium acetate afforded the corresponding 3,5–disubituted–2–(aminocarbonyl)–1,2,4–triazine–6–one (3). Acetylation of 3 with acetic anhydride yielded the monoacetyl and diacetyl derivatives (4 and 5). Methyl α–(p–chlorobenzoyl) amino–β–phenyl acrylate (6) was synthesized via the reaction of 2 with triethylamine in methanol. 5,6–disubstituted–4–hydroxypyrimidine–2–thiole (7) was obtained via cyclocondensation of ester (6) with thiourea in presence of anhydrous potassium carbonate. Synthesized compounds were characterized by EI–MS and NMR spectroscopy. The biological activity studies of triazines and pyrimidine–2–thiole were carried out against antioxidant and antitumor activities.