Volume : IX, Issue : V, May - 2019

Evaluation of clinical profile of Systemic Lupus Erythematosus

Anuj Singhal, Cs Mohanty, Dr Ca Tukaram

Abstract :

Objective: To evaluate the patterns and clinical characteristics of Systemic Lupus Erythematosus patients. Methods: This was an observational cross–sectional study conducted at a tertiary care centre in Mumbai. Patients who were diagnosed with Systemic Lupus Erythematosus (SLE) were enrolled in the study from 01 Jan 16 to 31 July 16. After history & clinical examination these patients were subjected to various diagnostic procedures so as to confirm the diagnosis of SLE. The clinical and immunological profile of all these patients was mapped to have better understanding of the disease pattern. Results: A total number of 11 SLE patients were enrolled with a mean age of 28.5 years. Gender distribution was found to be female preponderant (72.7%). Patients had involvement of various systems arthritis/arthralgia (64%), nephritis (45%), skin involvement/rashes (18%), adenitis (9%) and edema (9%). The patients were positive for antibodies like ANA, Anti Sm, Anti Ro, Anti La, U1RNP, Ro52 etc. As a standard of care, all the patients were previously taking dual or triple therapy comprising of a steroid with one or two of immunosuppressant for a mean duration of 2.9 years. The disease activity of these patients was evaluated using SLEDAI (SLE disease activity index); the mean value was 5.64. Consequently, all these patients were given steroids with steroid spå agents to which they showed good to moderate response. Conclusions: The observations of present study suggest that SLE patients may present with a wide variety of manifestations. Vigilant evaluation is required to diagnose the disease and its clinical pattern. Steroids and other immuno–suppressants can play an important role in management of these patients

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

EVALUATION OF CLINICAL PROFILE OF SYSTEMIC LUPUS ERYTHEMATOSUS, Anuj Singhal, CS Mohanty, Dr CA Tukaram INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-5 | May-2019

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