EVALUATION OF DEXMEDETOMIDINE FOR ATTENUATION OF HAEMODYNAMIC RESONSE TO TRACHEAL INTUBATION IN TREATED HYERTENSIVE PATIENTS: A COMPARISON WITH ESMOLOL

Raw B.K.; Malviya P.S.; Gupta Bhupesh K

Volume : VI, Issue : III, March - 2016

EVALUATION OF DEXMEDETOMIDINE FOR ATTENUATION OF HAEMODYNAMIC RESONSE TO TRACHEAL INTUBATION IN TREATED HYERTENSIVE PATIENTS: A COMPARISON WITH ESMOLOL

Raw B. K. , Malviya P. S. , Gupta Bhupesh K

Abstract :

Background: Hemodynamic response to laryngosccpy and tracheal intubation is exaggerated in hypertensive patients even though rendered normotensive pre–operatively by antihypertensive medications. Various studies have found that dexmedetomidine and esmolol can suppress the hemodynamic response to laryngoscopy and intubation. Objective: The present study was aimed to compare the efficacy of Dexmedetomidine with Esmolol in blunting hemodynamic response to tracheal intubation in treated hypertensive partients undergoing non– cardiac surgery under general anaesthesia. Methods: It was a prospective, double–blind, randomized, controlled study conducted at MLN Medical College & associated SRN Hospital, after approval from the institutional Ethical Committee. A total of 96 controlled hypertensive patients of either sex of age 18 to 60 years belonging to American Society of Anaesthesiologists (ASA) physical status I or II were randomly divided into three groups with 32 patients in each. In Group C, 10 ml of normal saline was injected i.v. 5 min prior to intubation. In Group D, Dexmedetomidine 0.5ug/kg bnody weight diluted in 10ml normal saline was given i.v. over 10 min, 10 min prior to intubation. In Group E, Esmolol 0.5 mg/kg body weight diluted in 10 ml normal saline was given i.v. over 1 min, 5 min prior to intubation. Heart rate (H.R.), systolic blood pressure (S.B.P.), diastolic blood pressure (D.B.P) & SP02, were measured prior to administration of drugs under study and then at 1,5,10 & 15 minutes post intubation. Results: Both the drugs, dexmedetomidine and esmolol were effective in controlling the heart rate after intubation however, dexmedetomidine stood better due to its more effective control of systolic and diastolic blood pressures and having additional analgestic and sedative properties.