Evaluation of Dexmedetomidine in attenuation of Symapathoadrenal Responses to Laryngoscopy and Intubation.

Volume : VIII, Issue : VII, July - 2018

Dr Khemraj Meena, Dr Santosh, Dr Sandeep Sharma

Background and Aims: Laryngoscopy is a basic and essential step during orotracheal intubation under general

anaesthesia but both laryngoscopy and intubation are associated with haemodynamic changes which are transient and

variable. These changes are well tolerated by normal healthy Patients but can be life threatening in compromised patients. Plan of our study is to

evaluate the effect of dexmedetomidine in attenuating the presser response to laryngoscopy and intubation in patients posted for elective surgery

under general anaesthesia.

Methods: It was a randomised, prospective, double–blind placebo–controlled study. After Institutional Ethical Committee clearance, fourty

patients of American Society of Anesthesiologists Physical Status 1 were enrolled in the study and divided into two equal groups. Group C

received normal saline 0.9% (20 ml) and Group D received Dexmedetomidine 0.5 μg/kg diluted up to 20 ml with 0.9% saline as infusion over 10

min before induction. Both groups were induced with standardised anaesthesia technique. The primary outcome measures were haemodynamic

response at 0, 1, 3, 5 and 10 min after intubation. The secondary outcome measures were to observe any side effects. The statistical package used

was SPSS version 15. Results: Groups were well matched for their demographic data. There was a statistically significant difference (P < 0.05)

between dexmedetomidine and normal saline in heart rate, systolic, diastolic and mean arterial pressures and Rate Pressure Product at all time

points after tracheal intubation. None of the patient had any adverse effects such as hypotension, adycardia, respiratory depression and

sedation. Conclusion: Intravenous dexmedetomidine in a dose of 0.5μg/kg is the good potion to attenuate stress response to laryngoscopy and

endotracheal intubation without any side effects.