Evaluation of Inflammatory Markers in Essential Hypertension

Rajesh Kumar Shrivastava; Nita Garg

Volume : VI, Issue : XI, November - 2016

Evaluation of Inflammatory Markers in Essential Hypertension

Rajesh Kumar Shrivastava, Nita Garg

Abstract :

Aim: The aim of our study was to evaluate serum uric acid and serum CRP levels in hypertensive patients and to compare it with normotensive subjects. Study design: A hospital based cross sectional study was conducted on patients attending the Out Patient Department of Medicine of SGRRIM&HS,Dehradun. A total number of 105 subjects (70 cases + 35 controls) in the age group (30 – 70 yrs)attending the Out Patient Department of Medicine of SGRRIM&HS,Dehradun and 35 healthy volunteers among the persons catering in various units of SGRRIM&HS,Dehradun were selected randomly for the study from Jan 2015 to Dec 2015. Both males and females with essential hypertension were included in the study. Serum uric acid and serum CRP was estimated in all cases and control subjects. Patients above 70 yrs and below 30 yrs, smokers, alcoholics, diabetics, patients suffering from cardiovascular disease and renal disorders were excluded from the study. Methodology: Biochemical and statistical analysis was done on all the 105 selected subjects. Serum Uric acid was estimated by enzymatic method (Uricase/Peroxidase) and serum CRP was estimated by noncompetitive Immunoassay method. Statistical analysis of each parameter was done and values were expressed in Mean ± SD. Result: The mean Systolic BP of the hypertensive patients were (149.5 ± 11.23) and the Mean Diastolic BP were (93.15 ± 10.98) mm of Hg, found much higher when compared with control cases. The mean serum CRP levels were 12.44 ± 9.41 mg/dl and mean serum Uric acid levels were 5.71 ± 1.42 mg/dl, both these values were much higher when compared with their control cases