Volume : IX, Issue : IV, April - 2019

Evaluation of liver enzymes in patients receiving Antiretroviral therapy containing protease Inhibitors.

Mani Goel, V S Chopra

Abstract :

Background– The high HIV/AIDS related morbidity and mortality in developed countries has been dramatically reduced by the beginning of effective combination of antiretroviral therapy or a cocktail of drugs. Objectives– To evaluate liver enzymes in HIV patients on protease inhibitors. Methods– The Study was conducted at ART Centre of LLRM Medical College, Meerut. The study was conducted over a duration of three years from September 2013 to August 2016. 280 patients were evaluated. Epi info 7 was used for analysis. Results– 240 (86%) were males and 40 (14%) were females, the highest prevalence was found in the age group of 31–40 years in males (60%) and 21–30 years in females (68%). most of the patients 95 (36%) were administered Nelfinavir, 40 (12%) patients were administered Lopinavir and Ritonavir, 47 (17%) patients were administered Indinavir. Conclusion– Frequent monitoring of Liver enzymes (AST, ALT and ALP) is necessary in all patients initiating HAART– including Protease inhibitors and concurrent Hepatitis treatment to avoid missing hepatotoxicity which is not included in routine tests.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

EVALUATION OF LIVER ENZYMES IN PATIENTS RECEIVING ANTIRETROVIRAL THERAPY CONTAINING PROTEASE INHIBITORS., Mani Goel, V S Chopra INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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