Volume : IX, Issue : I, January - 2019

EVALUATION OF LIVER TRANSAMINASES IN PATIENTS WITH SICKLE CELL DISEASE

Dr. Sushma Bj Chandrakar, Dr. Shrikant Chandrakar

Abstract :

Background: Sickle Cell Disease (SCD) is a life threatening autosomal recessive genetic disorder resulting from inheritance of abnormal genes from both parents. This disorder is prevalent in Central India along with other states like Maharashtra, Gujarat, Telangana, Odisha, Andhra Pradesh, Tamil Nadu and Kerala. SCD is frequently associated with liver disease resulting from multiple pathophysiological causes such as intrahepatic sinusoidal sickling, formation of gall stones (bilirubin stones), transfusion related hepatitis infections or excess iron deposition. Methods: 80 diagnosed and HPLC confirmed cases of SCD along with 80 age and gender matched controls were involved in the study. In all the cases and controls 5mL of random blood sample was drawn for biochemical analysis (liver function tests) after taking consent from the patients. Results: The serum total bilirubin, direct bilirubin, indirect bilirubin, aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher in SCD patients (P <0.001) than in controls. Conclusion: SCD patients had elevation of Transaminases and remaining liver function parameters compared to age matched controls. It is advisable that liver function tests be interpreted with caution in these patients. SCD patients require serial monitoring of these parameters during their routine visits to the hospital

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

EVALUATION OF LIVER TRANSAMINASES IN PATIENTS WITH SICKLE CELL DISEASE, Dr. Sushma BJ Chandrakar, Dr. Shrikant Chandrakar INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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