Volume : VII, Issue : IX, September - 2017

EVALUATION OF RISK MARKERS OF CVD IN METABOLIC SYNDROME

Bharat Kumar Gupta, Haren Baruah

Abstract :

 Background: Metabolic syndrome is one of the major public health issues with 30–40% probability of developing type 2 Diabetes Mellitusand/or cardiovascular disease.On extensive search of literature we could hardly find any study which could find a strong correlation between basal C–peptide and insulin levels as a risk marker for CVD and whatever was available the workers have tried to establish that high C–peptide levels coexists with hyperinsulinemia in metabolic syndrome.So we tried to explore the levels of C–peptide and insulin as a risk marker of CVD in the patients of metabolic syndrome.

Methods: After obtaining ethical clearance, a total of 267 patients of metabolic syndrome were selected and enrolled for the present study. All the patients were subjected to complete general and systemic examination and findings noted. Waist circumference was also recorded in all of them. The special investigations like lipid profile, LFT, KFT, fasting blood glucose, C–peptide and Insulin levels were estimated in all the cases and findings recorded and statistically analysed.

                       

Results:Out of the total of 267 subjects,15 (5.6%), 12 (4.5%) and 240 (89.8%) had C– peptide level <0.78 (mean± SD 0.49 ±0.24), 0.78–1.89 (mean± SD 1.35 ±0.45) and >1.89(mean± SD 6.14±3.47) respectively while in 3 (1.1%), 198 (74.1%) and 66 (24.7%) subjects, the insulin levels were found to be in <2 (mean± SD 1.8±0.0), 2–25 (mean± SD 13.05±26.58) and >25 (mean± SD 43.1±16.85) respectively.

Conclusion:

In our study 240 (89.8 %) subjects were having elevated C–peptide which is statistically significant (p<0.001), whereas only 66 (24.75) subjects had evaluated insulin level with no statistical significance. Therefore we came to a conclusion that fasting serum C–peptide levels is a better risk marker of CVD rather than fasting insulin levels in patients with Metabolic Syndrome.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Bharat Kumar Gupta, Haren Baruah, EVALUATION OF RISK MARKERS OF CVD IN METABOLIC SYNDROME, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-9 | September-2017

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