Evaluation of serum canavanine and creatinine levels in patients with chronical kidney disease before dialysis and after dialysis

Eliseo Ruiz Bedolla; Briceida Lopez Martinez; Israel Parra Ortega

Volume : X, Issue : II, February - 2020

Evaluation of serum canavanine and creatinine levels in patients with chronical kidney disease before dialysis and after dialysis

Eliseo Ruiz Bedolla, Briceida Lopez Martinez, Israel Parra Ortega

Abstract :

Background . Canavanine an amino acid arginine analogue is present in legumes and when ingested by animals creatinine is produced when it is metabolized; this amino acid is associated with the actívation or exacerbation of chronic kidney disease (CKD); therefore the aim of the present study was to know canavanine and creatinine levels in blood samples from patients with CKD immediately before dialysis and after dialysis. Material and methods. Serum canavanine levels were evaluated in 57 blood samples of patients with CKD to determine the levels of canavanine using the Rosenthal technic and creatinine with an autoanalyzer “ Dimension RxL” of Siemens. Results. The values obtained before dialysis for creatinine were from 3.0 to 14 mg/dl and canavanine from 10.0 to 21 mg/dl and after dialysis creatinine values were from 0.9 t0 7.5 mg/dl decreasing an average of 64% and the values for canavanine they were of 9.5 to 19 mg/dl. Conclusions. Our data indicate that the values of serum canavanine do not change after dialysis; therefore it is necessary to modify the composition of dialysis solution or to change the composition of semipermeable memane so that the canavanine levels decrease in blood of patients with CKD and serum creatinine levels do not continue to increase.