Evaluation of Serum CRP and Serum Uric acid levels in Rheumatoid Arthritis

Jyoti Shukla; Pankaj Sharma; Nita Garg

Volume : VI, Issue : VIII, August - 2016

Evaluation of Serum CRP and Serum Uric acid levels in Rheumatoid Arthritis

Jyoti Shukla, Pankaj Sharma, Nita Garg

Abstract :

Objective: The aim of our study was to quantity Sr. CRP and Sr. Uric acid in patients of Rheumatoid arthritis and to compare it with normal individuals of both sexes.Study Design: A hospital based cross sectional study was conducted on patients attending the Out patient Department of Orthopaedics of SGRRIMHS for a period of 7months from May 2015 to Nov 2015. A total no. of 102 patients (76 F +26 M) and 80 control cases (58 F + 22 M) in the age group 20 –60 yrs were selected randomly for the study. Exclusion criteria was age less than 20 yrs and more than 60 yrs, any previous history of DiabetesMellitus, Tuberculosis, Hypertension and cardiovascular disease.Methodology: All the 182 subjects, both 102 cases (76F +26M) and 80 controls (58F +22M) in the age group 20–60yrs were selected andthey underwent a biochemical analysis of RA factor, Sr CRP and Sr Uric acid. Sr. Uric acid was estimated by fully anutomated dry chemistry analyzer by Uricase/Peroxidase method(8), Sr. CRP was measured by Noncompetetive Immunerate assay(9) and RA factor by turbidimetric method (10) respectively.Result: The RA factor in females suffering from Rheumatoid Arthritis was much higher (47.78 ± 22.50 ±2.58units/ml) as compared to normal females (6.69 ± 2.55 ± 0.34 units/ml) and slightly higher as compared to Rheumatoid Arthritic males. The CRP in Rheumatoid Arthritic females was much higher (20.12 ± 11.58 ± 1.75mg/dl) as compared to normal females (5.82 ± 2.83 ± 0.39 mg/dl). The RA factor in Rheumatoid Arthritic males was again higher (46.86 ± 31.25 ±6.13 units/ml) than normal males (7.58 ± 3.14 ± 0.68 units/ml). Similarly Sr. CRP was also found to be higher in Rheumatoid Arthritic males (32.62 ± 24.95 ± 5.73 mg/dl) as compared to normal males ( 5.73 ± 2.54 ± 0.6 mg/dl). No significant correlation was found in the values of Uric acid for both males and females.