Volume : VI, Issue : III, March - 2016

EVALUATION OF SERUM NITRIC OXIDE AS A DIAGNOSTIC AND PROGNOSTIC MARKER IN PATIENTS WITH HEPATOCELLULAR CARCINOMA STARTING LOCO–REGIONAL THERAPY

Afifi F. Afifi, Osama M. Basha, Waseem M. Seleem, Raghda A. Hafez, Ayman M. El Fateh

Abstract :

<p><p> Background: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. HCC is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. Aim of the study: To evaluate the level of serum nitric oxide as a diagnostic and prognostic marker for patients with HCC subjected to Loco–Regional therapy. Patients and Methods: The study included 30 patients with HCC candidate for loco–regional therapy and 15 cirrhotic non–HCC patients as control subjects. Basal serum nitric oxide level was measured in both groups with assessment of its level after one month for HCC patients subjected to loco–regional therapy. Results: Serum nitric oxide level was proved to rise in patients with HCC rather than cirrhotic non–HCC patients (120 ± 37.9 vs. 68.7 ± 20µmol/L respectively; p<0.001). Significant reduction of serum nitric oxide level was recorded one month after loco–regional therapy when compared to the basal level (120 ± 37.9 vs. 89 ± 29.7 respectively; p<.001) together with good clinical and radiological response. Conclusions: The study concluded that serum nitric oxide can be used as a novel diagnostic marker for HCC together with a strong impact on the success of loco–regional therapy giving it a prognostic value.</p></p>

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Afifi F. Afifi, Osama M. Basha, Waseem M. Seleem EVALUATION OF SERUM NITRIC OXIDE AS A DIAGNOSTIC AND PROGNOSTIC MARKER IN PATIENTS WITH HEPATOCELLULAR CARCINOMA STARTING LOCOâ�‚�“REGIONAL THERAPY Indian Journal of Applied Research, Vol.6, Issue : 3 March 2016

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