Evaluation of the Effect of Dexmedetomidine infusion on outcome of COPD patients on non–invasive ventilation

Sujata Singh; Vipin Kumar Singh; Rita Wahal; Rajiv Ratan

Volume : VIII, Issue : VI, June - 2018

Evaluation of the Effect of Dexmedetomidine infusion on outcome of COPD patients on non–invasive ventilation

Sujata Singh, Vipin Kumar Singh, Rita Wahal, Rajiv Ratan

Abstract :

Objective: To evaluate of the Effect of Dexmedetomidine infusion on outcome of COPD patients on non–invasive ventilation.

Methods: Enrolled patients were randomly allocated to a (Dexmedetomidine) DEX group A (n=35) or (0.9% saline) control group B (n=35) using a randomized sequence generated by a computer, randomization process was centralized. The participating patients and nurses were blinded to the treatment.

Results: Differences in mean blood oxygenation were found to be statistically significant at all the follow up periods. Mean dyspnea grading of Group B (8.51±1.22) was found to be higher than that of Group A (7.09±1.31) and difference in dyspnea grading of both the groups at 1 hr. was found to be statistically significant (p<0.001). Comparison of mean heart rate between two groups showed significant stability in both the groups. ICU stay of patients of Group A ranged from 2–6 days while that of Group B from 9–17 days. Difference in mean ICU stay in patients of Group A (4.37±1.09 days) and Group B (12.23±1.94 days) was found to be statistically highly significant (p<0.001).

Conclusion:The desired level of oxygenation and improved outcome obtained by the effect of Dexmedetomidine on Non–invasive ventilation treatment in COPD patients improved many important aspects of critical care compared with the conventional treatment.