EVALUATION OF XANTHIUM INDICUM LEAF EXTRACT AND  –TOCOPHEROL ON ANTIOXIDANT DEFENCE SYSTEM AND ON SELECTED RENAL MARKERS IN STZ INDUCED DIABETIC RATS

Anila Devi Meruva; Sathyavelu Reddy Kesireddy

Volume : VII, Issue : VI, June - 2017

EVALUATION OF XANTHIUM INDICUM LEAF EXTRACT AND –TOCOPHEROL ON ANTIOXIDANT DEFENCE SYSTEM AND ON SELECTED RENAL MARKERS IN STZ INDUCED DIABETIC RATS

Anila Devi Meruva, Sathyavelu Reddy Kesireddy

Abstract :

Introduction: Chronic kidney disease (CKD) is a major public health problem, especially for people suffering with diabetes. Herbal formulations have attained widespread acceptability as therapeutic agents in many developing countries as anti–diabetic as well as renoprotective agents. Xanthium indicum (Asteraceae) has been reported with number of medicinal properties and α–tocopherol is a well known antioxidant cause nephro protection by improving the antioxidant enzyme activity and also lowering the levels of urine microalbumin and serum cystatin C in diabetic rats. The present study was to investigate the ameliorative property of hydromethanolic leaf extract of Xanthium indicum and α–tocopherol under hyperglycemic condition associated with kidney damage. Methods: seven groups of male albino rats six in each group, received the following treatment scheduled for 4 weeks: Normal control, Xanthium indicum, α–tocopherol, Diabetes control, Glibenclamaide8 treated diabetic, α–tocopherol treated diabetic and Xanthium treated diabetic. Evaluations were made for the activites of antioxidant enzymes like SOD, CAT, GPX and levels of urine microalbumin and serum cystatin C by the method of nephelometry in all experimental rats. Results: A significant improvement in the activities of SOD (P < 0.05), CAT (P < 0.001) and GPx (P<0.001) and microalbumin in urine (P<0.001) and serum cystatin C levels (P<0.001) were significantly decreased with the treatment of plant extract and α–tocopherol in diabetic rats. Conclusion: Hydromethanolic extract of Xanthium indicum leaves and α–tocopherol possesses a potent capacity that attenuated the nephrotoxicity by lowering urine microalbumin and serum cystatin C levels in diabetic conditions.