Evidence of Teratogenicity and DNA Damage among Women with Second Trimester Abortions

Swapna C Senan; Sumitha Prabhu PS; Sumina Cherian; Sarala Gopalakrishnan; Dinesh Roy D

Volume : VI, Issue : VI, June - 2016

Evidence of Teratogenicity and DNA Damage among Women with Second Trimester Abortions

Swapna C Senan, Sumitha Prabhu Ps, Sumina Cherian, Sarala Gopalakrishnan, Dinesh Roy D

Abstract :

 Second trimester pregnancy loss is uncommon, but it should be regarded as an important event in a woman’s obstetric history. The exposure of various teratogen lead to DNA damage and subsequent chromosomal abnormalities. These factors play a major role in second trimester abortion. The study consists of 40 women with second trimester abortion/s and 15 healthy subjects without any chronic illness were selected as control for the study. The goal of the present study was to evaluate the effect of teratogenicity and extent of somatic DNA damage in subjects with second trimester abortion. The extent of somatic DNA damage is quantified by Cytokinesis Block Micronuclei (CBMN) assay. Detailed demographic and clinical characteristics were recorded and compared. The present study demonstrated that micronuclei frequency was significantly elevated in the study subjects than control subjects. Maternal problems such as history of infection, increased duration of married life, thyroid disorders, diabetes etc can leads to foetal loss. Modification of lifestyle along with proper preventive measures against teratogenic infection and awareness of the role of genetics in the etiology of recurrent pregnancy loss will help in reducing the risk for miscarriage.