Volume : V, Issue : IV, April - 2015

Experimental Study on the Role of 5–HT3 Serotonin Receptors in the Mechanism of Anti–Inflammatory and Antihyperalgesic Action of Antidepressant Fluoxetine

Ilia Kostadinov, Delian Delev,

Abstract :

The aim of the present study is to determine the role of 5–HT3 receptors in the mechanism of anti–inflammatory and antihyperalgesic action of antidepressant fluoxetine after single and repeated administration. 

Carrageenan–induced paw edema and test with mechanical pressure of inflamed paw were used. Fluoxetine showed 
significant anti–inflammatory and antihyperalgesic effect when compared with the control. After long–term treatment 
and in the first four hours, after single administration ondansetrone (5–HT3 antagonist) did not change significantly the 
anti–inflammatory effect of fluoxetine. At 24 hours in single dose treated animals the combination did not differ statistically when compared with the control. After acute and prolonged treatment the group that received fluoxetine + 
ondansetrone showed a statistically significant increase in paw pressure to withdraw the hind paw compared with that 
treated with fluoxetine alone. Fluoxetine has anti–inflammatory and antihyperalgesic effect, which is mediated through 
the action of serotonin on 5–HT3 receptors.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Ilia Kostadinov, Delian Delev, Experimental Study on the Role of 5–Ht3 Serotonin Receptors in the Mechanism of Anti–Inflammatory and Antihyperalgesic Action of Antidepressant Fluoxetine Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015


Number of Downloads : 698


References :