Volume : VI, Issue : X, October - 2016

Fecal Calprotectin India perspective Role in diagnosis of patients with chronic non�bloody diarrhea

Dr Reuben Thomas Kurien

Abstract :

 • Aims: Fecal calprotectin (FC) has been found to be a marker of intestinal inflammation particularly in the context of inflammatory bowel disease in the West. This study was thus done to evaluate the efficacy of Fecal Calprotectin as a screening test to discriminate organic from functional diarrhea. • Methods: Eighty three adult patients with chronic diarrhea of unknown origin were consecutively enrolled in this study. Fecal Calprotectin was also measured by ELISA. • Results: Patients with organic diarrhea included Inflammatory Bowel Disease (IBD), Parasites, Polyps. Fecal Calprotectin showed a sensitivity of 70 % (CI 56–82%) and specificity of 60% (CI 45–72%) for the diagnosis of organic diarrhea using a cut off at 250μg/g. • Conclusions: Fecal Calprotectin was found to be a reliable biomarker of intestinal inflammation in patients with chronic diarrhea of unknown origin. The best estimate cut off of Fecal Calprotectin in our population appears to be >250μg/g to distinguish organic from functional disease and >600μg/g to diagnose inflammatory bowel disease.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Reuben Thomas Kurien Fecal Calprotectin India perspective Role in diagnosis of patients with chronic non�bloody diarrhea Indian Journal of Applied Research,Volume : 6 | Issue : 10 | October 2016

Number of Downloads : 609

References :

<p><pre></pre></p>