FREE RADICAL AND ANTIOXIDANTS IN OBESE DIABETICS AND NORMAL BMI DIABETICS

Pal AK; Badade  ZG; Rai S; Gawali S

Volume : V, Issue : X, October - 2015

FREE RADICAL AND ANTIOXIDANTS IN OBESE DIABETICS AND NORMAL BMI DIABETICS

Pal Ak, Badade Zg, Rai S, Gawali S

Abstract :

India has a high prevalence of diabetes mellitus and the numbers are increasing at an alarming rate. In India alone, diabetes is expected to increase from 40.6 million in 2006 to 79.4 million by 2030. The problems of obesity and impaired glucose tolerance are not confined to adults alone but children are also increasingly getting affected. Most long standing macro and micro vascular complications are also more common among Indian diabetics as compared to other races and ethnic groups. Aim:– To study free radical and antioxidant status in type 2 diabetes mellitus with respect to obesity. Meterial and Methods:– Present study was prospective, carried out in the Department of Biochemistry, MGM Medical College and Diabetology clinics of MGM Group of Hospitals, Vashi, Belapur & Kamothe, Navi Mumbai. 80 type–2 diabetic patients of both genders aged between 35 to 65 years were divided into two groups. Group–1 comprised of 40 obese diabetes, Group–2 40 nomal BMI diabetics and 40 healthy individuals acted as control Group–3. Oxidative stress markers MDA, NO and antioxidants SOD and Catalase were estimated. Results:– Oxidative stress makes MDA (3.04 ± 0.54) (nmol/ml) and NO (42.26 ± 12.25) (µmol/L) were highest while antioxidants SOD (1.29 ± 0.31) (U/ml) and catalase (16.75 ± 0.11) (U/mg) were least in obese diabetics. Conclusion:– Obesity and diabetes plays an important role in the development of increased oxidative stress and associated complications leading to easier memane lipoperoxidability and memane damage. Obesity increases oxidative stress synergistically in type–2 diabetes mellitus.