Volume : V, Issue : VI, June - 2015

From drugs targeting serotonin pathways to the fracture risk

Mara Carsote

Abstract :

 The serotonin is connected to the bone homeostasis because the peripheral molecule stimulates bone loss and it has a positive bone mass effect by the neural central skeleton control. The drugs as selective serotonin reuptake inhibitors (SSRI) interfere in the serotonin pathways by displaying more serotonin to the bone. Thus the risk of fracture is augmented and clinical data pointed significantly deficit in the bone mineral density after long term use. Also, an increased risk of fall especially at the begging of the therapy is seen mainly related to cardiovascular events as arrhythmias, syncope, and hypotension. Nevertheless, the depression itself has a negative impact on bone mineral density and to the overall risk of fracture other potential mechanism are registered: vitamin D deficit, obesity, etc. The tools to assess the fracture risk are central Dual–Energy X–Ray Absortiometry and perhaps the bone turnover markers, but not currently plasma serotonin assay.

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Article: Download PDF   DOI : 10.36106/ijar  

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Mara Carsote From drugs targeting serotonin pathways to the fracture risk

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