Volume : IV, Issue : XI, November - 2014
Functional Mri After Internal Limiting Membrane Peeling for Symptomatic Lamellar Macular Hole and Macular Pseudoholesurgery
Jan Lestak, Jaroslav Tintera, Jan Kalvoda, Zuzana Svata, Bohdana Kalvodova, Ivan Karel, Pavel Rozsival
Abstract :
The aim of the study was to determine whether the epimacular memane (EMM) and internal limiting memane (ILM) peeling for symptomatic lamellar macular hole (LMH) and macular pseudohole (MPH) will lead to reductionof functional MRI (fMRI) response in the visual cortex of the ain. The pilot study involved 20 eyes of 10 patients (7 female and 3 male) with a mean age of 75 (66–83 years) who underwent pars planavitrectomy. The other eye served as a control. Patients did not suffer from any other ocular or neurological disease. All the patients underwent fMRI examinations with stimulation of both eyes separately using an alternating black and white checkerboard. The number of activated voxels in the visual cortex gained for each eye was compared by means ofstandard data evaluation using the general linear model (T–map threshold of P=0.05 with family–wise error correction), and paired T–test was used for statistical evaluation of this difference. All patients showed a decrease of fMRI ain activation after stimulation of the eye where surgical intervention was performed. The analysis showed a statistically significant difference between the operated and non–operated eye (P= 0.0049). Patients with symptomatic partial macular defects after EMM and ILM peeling showed a decrease of the fMRI ain activity after stimulation of the operated eye.  
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DOI : 10.36106/ijar
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Jan Lestak,Jaroslav Tintera,Jan Kalvoda,Zuzana Svata,Bohdana Kalvodova,Ivan Karel,Pavel Rozsival Functional Mri After Internal Limiting Membrane Peeling
for Symptomatic Lamellar Macular Hole and Macular Pseudoholesurgery Indian Journal of Applied Research, Vol.4, Issue : 11 November 2014
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Jan Lestak,Jaroslav Tintera,Jan Kalvoda,Zuzana Svata,Bohdana Kalvodova,Ivan Karel,Pavel Rozsival Functional Mri After Internal Limiting Membrane Peeling for Symptomatic Lamellar Macular Hole and Macular Pseudoholesurgery Indian Journal of Applied Research, Vol.4, Issue : 11 November 2014
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