Gestational Trophoblastic Neoplasia - An Experience of a Tertiary Medical College in Eastern India

Dr. Niladri Roy; Dr. Joydeep Basu

Volume : IX, Issue : III, March - 2019

Gestational Trophoblastic Neoplasia - An Experience of a Tertiary Medical College in Eastern India

Dr. Niladri Roy, Dr. Joydeep Basu

Abstract :

Gestational Trophoblastic Neoplasia is a rare gynaecological tumour. Between March 2016 and June 2018, fourteen (14) Gestational Trophoblastic Neoplasia patients, diagnosed either histopathologically or by imaging and raised serum β hCG level were evaluated. After risk categorization according to WHO guideline, nine patients with low risk disease were treated with Inj. Methotrexate. Two of them required Inj. Actinomycin – D due to Methotrexate resistance. Five high risk patients were treated with EMACO (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide and Vincristine) regimen. One resistant case was treated with second line EMA/EP regimen (Etoposide, Methotrexate, Actinomycin D, Cisplatin). After treatment patients were followed with serial serum β hCG level for one year. All the patients were asymptomatic with normal β hCG level during the period. Treatment related toxicities were manageable. Gestational Trophoblastic Neoplasia is a highly chemosensitive and curable disease even in high risk patients with acceptable toxicities.