Volume : IX, Issue : IV, April - 2019

GLYCEMIC STATUS IN ORGANOPHOSPHORUS POISONING–A PROSPECTIVE ANALYTICAL STUDY.

Dr. Viney Sambyal, Dr. Vijant Singh Chandail

Abstract :

Background: Organophosphorus(OP) poisoning, in addition to its cholinergic manifestations shows metabolic derangements leading to hyperglycemia. Apart from inhibiting acetylcholinesterase it also induces oxidative stress to exhibit this manifestation. The present study aims to assess the glycemic status of OP poisoned patients and its association with various factors in OP poisoning like oxidative stress and dose of atropine. Methods: This is a prospective study which recruited 350 patients above 18 years of age with history of OP poisoning. They were categorized into 3 grades–mild, moderate and severe based on the Peradeniya Organophosphorus Poisoning Scale. Results: A prospective analytical study of 350 patients of acute organophosphate poisoning was done and on the basis of blood glucose levels at the time of presentation were further categorised into euglycemics (64%) and hyperglycaemics (36%). The outcome in terms of complication rate was 22.1%and 77.9% in the respective groups. The ventilator requirements among the two groups were 6 and 12 patients respectively. Chisquare test to study the association between the presentation Random Blood Glucose (RBG) and the established Peradeniya Organophosphorous Poisoning Scale (POP) and Poisoning Severity Scale (PSS) revealed the study to be statistically significant (p value<0.005)indicating that the extreme of glycemic status was associated with higher clinical severity and poorer outcomes. Conclusion: We conclude that the glycemic status at the time of presentation in acute organophosphate poisoning patients is a simple, cheap, reliable marker in guiding the clinical severity and outcome when considered with clinical severity scores

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

GLYCEMIC STATUS IN ORGANOPHOSPHORUS POISONING-A PROSPECTIVE ANALYTICAL STUDY., Dr.Viney Sambyal, Dr.Vijant Singh Chandail INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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