GRAM POSITIVE BACTERIAL PATHOGENS IN ACUTE EXACERBATION OF COPD AND ANTIBIOTIC SENSITIVITY PATTERN OF THESE ORGANISMS

V.Viswambhar; B.Sowjanya; N.Meenakshi; Dr Aruna Shanmuganathan; S.Subramanian; Vishnu Sharma.M

Volume : VI, Issue : IV, April - 2016

GRAM POSITIVE BACTERIAL PATHOGENS IN ACUTE EXACERBATION OF COPD AND ANTIBIOTIC SENSITIVITY PATTERN OF THESE ORGANISMS

V. Viswambhar, B. Sowjanya, N. Meenakshi, Dr Aruna Shanmuganathan, S. Subramanian, Vishnu Sharma. M

Abstract :

Introduction: Knowledge of common bacterial pathogens and their sensitivity pattern to antibiotics will help in early proper institution of appropriate antibiotic therapy in AECOPD. Materials and methods: Sputum culture and sensitivity was done in 90 patients admitted with AECOPD. Those patients with gram positive bacterial infection on sputum culture were analysed for antibiotic sensitivity pattern. Results: Gram positive organisms were isolated in 29 cases. Most common was streptococcus pneumoniae (45%), followed by streptococcus pyogenes (34%). 100% of Streptococcus pneumoniae were sensitive to 3rd generation cephalosporins (p=0.0001 CI 95) and Piperazillin+ Tazobactum, 89% were susceptible to Levofloxacin. 80% were susceptible to ciprofloxacin. Streptococcus pyogenes was susceptible for both Ciprofloxacin & Levofloxacin. Conclusions: The most common gram positive organism in our study causing AECOPD was streptococcus pneumoniae followed by streptococcus pyogenes. Initial emperical antibiotic therapy can be started with a 3rd generation cephalosporin or ciprofloxacin.