Granulosa cell tumor ovary associated with endometrial adenocarcinoma– A case report

Richika Gupta; Manjit Kaur; Parvinder Sandhu; Deepak Arora; M.K. Mahajan; Karuna Singh

Volume : VIII, Issue : IX, September - 2018

Granulosa cell tumor ovary associated with endometrial adenocarcinoma– A case report

Richika Gupta, Manjit Kaur, Parvinder Sandhu, Deepak Arora, M. K. Mahajan, Karuna Singh

Abstract :

Ovarian granulosa cell tumors represent uncommon neoplasms (2–5% of all ovarian neoplams) with estrogen–secreting capacity. Due to their association with persistently increased levels of estrogen, modifications of the endometrial tissue ranging from hyperplasia to malignant transformation may be encountered. The incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, most of these endometrial cancers are well–differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.

We present the case of a 45–year–old patient who presented with excessive vaginal bleeding. The endometrial biopsy raised the suspicion of an atypical endometrial hyperplasia and the patient was submitted to surgery. Histopathological studies of the specimen of total hysterectomy with bilateral salpingo–oophorectomy revealed the presence of a well–differentiated endometrial carcinoma associated with a granulosa cell tumor of the ovary. In conclusion, a high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis as the association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare.