Green And Efficient Microwave One Pot Synthetic Approach to N–Phenyl Piperazinyl–1,3,4–Oxadiazole Derivatives and Evaluation of Their Antioxidant and Anti Inlammatory Activity

NEETU BHARATIYA; CHANDRA PRAKASH GHARU

Volume : IV, Issue : XI, November - 2014

Green And Efficient Microwave One Pot Synthetic Approach to N–Phenyl Piperazinyl–1,3,4–Oxadiazole Derivatives and Evaluation of Their Antioxidant and Anti Inlammatory Activity

Neetu Bharatiya, Chandra Prakash Gharu

Abstract :

A green efficient one pot synthetic protocol has been developed for 2 phenyl–piperazino–5–mercapto–substituted aryl–1,3,4–oxadiazoles. Synthesized compounds were characterized by FTIR, 1H NMR and elemental analysis. Antioxidant activity of methanol solutions of synthesized compounds was determined by Reducing power assay and Hydrogen peroxide scavenging activity at 700 nm and 250 nm respectively. The synthesized compounds were also screened for anti–inflammatory activity. Compound showed good anti–inflammatory and antioxidant activity.