Volume : VII, Issue : VI, June - 2017

GREEN COW DUNG POWDER– (Malachite greenpoisoning) – STUDY OF CLINICAL PROFILE, AND STATREGIES OF MANAGEMENT

Dr. A. Muruganathan, Dr. M. Venkatesh, Dr. T. Ravikumar, Dr. S. Angayarkanni, Dr. P. Saravanan, Dr. Sopna Jothi

Abstract :

 Introduction; Malachite green is an organic compound that is used as a dyestuff and controversially as an antimicrobial in aquaculture. Malachite green is traditionally used as a dye for materials such as silk, leather, and paper. Although called malachite green, this dye is not prepared from the mineral malachite – the name just comes from the similarity of colour Malachite green  is a tasteless , odour less water soluble ,easily available household highly lethal poison which ia a suicidal agent causing morbidity and mortality  of  HUNDREDS OF people in Coimbatore Tirupur and Erode districts of western part of Tamilnadu every year Aim of the study  this is a prospective study to analyze the clinical presentations , biochemical changes in patients with green  cow dung powder poisoning, Materials and methods all the patients admitted in tertiary care  govt medical college hospitals with history of alleged cowdung powder poisoning are taken for study Results . As there are no specific antidotes for chemicals such as the synthetic cow dung powder, we would like to mention the usefulness of alkalinization of urine in synthetic cow dung powder poisoning. The dye in cow dung powder has weak acidity and if ingested orally, major component of it gets eliminated through renal excretion.[2] Alkalinisation promotes the solubility of dye, especially malachite green which otherwise gets precipitated in the kidney and results in renal failure. Hence, it is worth to administer soda bicarbonate which enhances excretion of the component through urinary alkalinisation.[2] Moreover, early administration of soda bicarbonate minimizes the distribution of toxins into other tissues and enhances elimination of the toxins that exist in equiliium between an ionized and unionized state.[3] As the unionized toxins cross cellular barriers and lead to increased toxicity, it is good to keep the toxins in an ionized state which is theoretically desirable. Hence, serum alkalinisation reduces the distribution of the toxin/dye into the central nervous system and curtails the occurrence of seizures.[4] As the ionized form has low lipid and high water solubility, it remains "trapped" in the renal tubules and thereby prevents resorption of the toxins by the kidneys and enhances elimination in urine. This concept is often referred to "ion trapping." Hence, we suggest the use of continuous infusions of soda bicarbonate to prevent the undue events in cow dung powder poisoning.[4] Moreover, the practitioners have to be informed to motivate their cases for follow–up, in view of its cytotoxicity and teratogenicity. As these types of poisoning contribute to morbidity and mortality, translational research activities have to be undertaken on these toxins, and therapeutic guidelines have to be provided. Many a time, locally available materials may be helpful as observed in cow dung powder poisoning.[4] The old adage "when there is a will, there is a way" holds good for synthetic cow dung poisoning.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.A.Muruganathan, Dr.M.Venkatesh, Dr.T.Ravikumar, Dr.S.Angayarkanni, Dr.P.Saravanan, Dr.Sopna Jothi, GREEN COW DUNG POWDER– (Malachite greenpoisoning) – STUDY OF CLINICAL PROFILE, AND STATREGIES OF MANAGEMENT, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017

Number of Downloads : 515

References :