Volume : V, Issue : IV, April - 2015
Green Synthesis of Benzoin Derivatives Using Coenzyme Catalyzed Benzion Condensation Reaction.
Anandrao Kale
Abstract :
The new trends of Green Chemistry is an invention, design, development and application of chemical products and processes to reduce or to eliminate the use and generation of substances hazardous
to human health and environment. The Benzoin and its derivatives are synthesized by conventional method by use of
sodium cyanide and ethanol with strong heating for the longer time which is found to hazardous and slower conversion
An alternative facile route of green approach, eco–friendly and solvent–free reaction procedure with very simple workup
conditions is needed for organic synthesis. Present work is carried out for the synthesis of Benzoin and its derivatives
by coenzyme catalyzed benzion condensation reaction. The synthesis of ligands benzoin and its substituted derivatives
includes three component coupling reaction of benzaldehyde, ethanol and sodium hydroxide. The ice cold clear solution of thiamine hydrochloride in aqueous ethanol is taken in a 50 ml round bottom flask. To this ice cooled freshly
prepared (15 ml) sodium hydroxide solution is added. Then Fresh bidistilled benzaldehyde (10 ml) or substituted benzaldehyde was added to the reaction mixture. The mixture was heated gently on a water bath for about 60 min. The
mixture was cooled to room temperature and then in ice bath to induce crystallization of the benzoin. The yield is 45%
and melting point is found to be 1350C. The ligands obtained is recrystallized; and further characterized by modern
spectral methods. The systematic path of the reaction and mechanism is shown in the Scheme–I. The peculiarity of the
reaction is rapid conversion, solvent free; no use of catalyst and hazardous chemicals in the synthesis hence, it is ecofriendly green chemistry synthesis.
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DOI : 10.36106/ijar
Cite This Article:
Anandrao Kale Green Synthesis of Benzoin Derivatives Using Coenzyme Catalyzed Benzion Condensation Reaction. Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
Number of Downloads : 4334
Anandrao Kale Green Synthesis of Benzoin Derivatives Using Coenzyme Catalyzed Benzion Condensation Reaction. Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
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