Hematological and Molecular Cytogenetic Studies in Hypertensive Subjects

Sharmila K; Reshmi R; Sajina A; Girija V; Viji Krishnan; Dinesh Roy D

Volume : VI, Issue : VII, July - 2016

Hematological and Molecular Cytogenetic Studies in Hypertensive Subjects

Sharmila K, Reshmi R, Sajina A, Girija V, Viji Krishnan, Dinesh Roy D

Abstract :

Hypertension is a major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular disease. The prevalence of hypertension worldwide is projected to increase from approximately 1.0 billion in 2000 to 1.5 billion by 2025. Elevated BP results from environmental factors (diet, physical inactivity, toxins and psychosocial factors) and genetic factors. Hypertensive subjects have an increase in blood plasma viscosity, and in memane rigidity of red blood cells (RBCs), a reduction of their ability to pass through microcapillary, changes in erythrocyte aggregation and disaggregation, high hematocrit and increased amounts of fiinogen and triglycerides. Hemorheologic action alters microcirculation and increase cardiovascular risk in hypertensive patients. The study consists of fifty four hypertensive individuals with varying risk factors were selected as study subjects and 30 healthy individuals without any chronic illness were selected as control for the study.The aim of the present study was to investigate the hematological and molecular cytogenetic studies in subjects with hypertension. Detailed demographic, clinical and hematological characteristics were recorded and compared. The present study demonstrated that micronuclei frequency was significantly elevated in the study subjects than control subjects. Increased levels of somatic DNA damages were observed in hypertensive subjects with more risk factors associated with genetically based conditions and demographic variables. Abnormal values of hematological and biochemical characters were compared to normotensive subjects. Lifestyle modifications by increasing physical exercise and dietary control will help to lower blood pressure.