Volume : VI, Issue : IV, April - 2016

Hemoglobin level increases during the first detected phase of overt diabetes mellitus

Dr, Sankar Roy, Dr, Tapan Debnath, Dr. N. Gan Chaudhuri

Abstract :

 Diabetes Mellitus is a metabolic disease where due to hyperglycemia multiple complications are manifested in the course of time. Persistent hyperglycemia causes irreversible glycosylation of the hemoglobin called HbA1c. Glucose is converted to L–deoxyfructose. Glycosylation increases with the increase of hyperglycemia and also with the duration of suffering. It is a very stable compound and remains bound throughout the life span (120 days) of Red Blood Cells. Blood HbA1c level > 6.5 % is considered as criterion for the diagnosis of diabetes. Increased HbA1c shifts the oxyhemoglobin dissociation curve to the left reducing the hemoglobin’s ability to release the oxygen at the tissue bed. This causes relative hypoxia in the tissues. Erythropoietin ( EPO), a glycoprotein produced in the kidney is the major humoral regulator of Rbc production. Hypoxia induces increased synthesis of EPO. Therefore, hemoglobin level also increases. In the present study it is found that hemoglobin level of all the newly detected diabetic patients were high as compared to normal individuals . For male diabetic patients it was 15 (+0.87) gm/dl and for female it was 14 (+0.83) gm/dl as compared to the control 13.14 (+1.34) gm/dl and 12.15 ( + 0.87)gm/dl respectively. After receiving hypoglycemic drugs HbA1c level falls and tissue hypoxia reduces. Hemoglobin level also comes down to normal level.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr, Sankar Roy, Dr, Tapan Debnath, Dr. N. Gan Chaudhuri Hemoglobin level increases during the first detected phase of overt diabetes mellitus Indian Journal of Applied Research, Vol.6, Issue : 4 April 2016

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