Hepatic Amyloidosis Secondary to Schiatosomal  Infection: Therapeutic Effect of Colchicines Alone or  in Combination with Praziquantel

Mahmoud Saad; M.S. Al-Ghrib; Ayman El-Baz; Sahar Hamed

Volume : III, Issue : VI, June - 2013

Hepatic Amyloidosis Secondary to Schiatosomal Infection: Therapeutic Effect of Colchicines Alone or in Combination with Praziquantel

Mahmoud Saad, M. S. Al Ghrib, Ayman El Baz, Sahar Hamed

Abstract :

Amyloid deposits is one of the most complication were found secondary to schistosomal infection in both human and experimental animals. We aim to study the effect of common used amyloidosis drug "colchicines" for the treatment of secondary amyloidosis of schistosomal infection. Hamsters were infected with 200 S. haematobium cercariae and treated with Colchicines (Col) or/ and Prazequentel (PZQ), early and late of infection. Biochemical and histopathological investigations were measured to assess the effect of Col or/ and PZQ treatment. Significant reduction in hepatic Amyloid deposits and improvement in serum albumin and cholesterol were observed when combined treatments were given. This was nearly complete with early treatments and only partial when treatment was given late. We conclude that, colchicine is effective for the prevention of and cure hepatic amyloidosis secondary to schistosomal infection.