Hepatotoxic changes induced by prenatal administration of olanzapine in swiss albino mice

SOUMYA KHANNA; ANAND MISHRA; SK PANDEY

Volume : V, Issue : X, October - 2015

Hepatotoxic changes induced by prenatal administration of olanzapine in swiss albino mice

Soumya Khanna, Anand Mishra, Sk Pandey

Abstract :

Introduction : Olanzapine is an atypical antipsychotic drug approved by FDA for the treatment of psychotic disorders. Although atypical antipsychotics have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased , with maternal atypical antipsychotic use. But its effect on fetal liver is yet to be ascertained. Materials and methods : pregnant albino mice was given olanzapine in the dose of 0.2 mg/kg and amount of distilled water during the same period. On day 19th the mice was sacrificed and fetuses were taken out. The liver of fetuses were dissected, formalin fixed , processed and stained with H&E for histological study. Results : On gross examination liver of 2mg/kg group showed marked reduction in size of liver. On histological examination in the treated group there is decreased density of haemoprogenitor cells as well as hepatoblasts. The progenitor cells and hepatoblasts shows degeneration with pyknotic nuclei, karyolysis and karyorhexis. Conclusion: olanzapine causes hepatotoxicity in fetus if given to mother during pregnancy and should be used with caution in pregnancy