HER�2/NEU EXPRESSION IN COLORECTAL CARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGIC VARIABLES

Dr.N. Vani; Dr. M. Sumathi; Dr. V.Praba; Dr.P. Kalaivani

Volume : VII, Issue : III, March - 2017

HER�2/NEU EXPRESSION IN COLORECTAL CARCINOMA AND ITS CORRELATION WITH CLINICOPATHOLOGIC VARIABLES

Dr. N. Vani, Dr. M. Sumathi, Dr. V. Praba, Dr. P. Kalaivani

Abstract :

Background: Colorectal cancer is one of the most common leading causes of cancer related mortality and account for approximately 9% of all human cancers. Immunohistochemical marker such as HER–2/neu can be used for the diagnosis and prognosis of colorectal adenocarcinoma. Aims and objectives: To study the immunohistochemical overexpression of HER–2/ neu and its correlation with clinico pathologic variables and its role in targeted therapy. Materials and methods: Histomorphological and immunohistochemical pattern of expression of HER–2/ neu were studied and analysed for 60 cases of colorectal adenocarcinoma specimens received over the period of two years. Results: Out of total sixty cases studied 40 cases were HER–2/neu positive and 20 cases were HER–2/neu negative which constitutes 67% and 33% respectively. Conclusion: The rate of HER–2/neu expression in colon carcinoma is high.